The use of birth control pills decreases the risk of developing endometrial cancer by half. At Significantly Higher Risk • Postmenopausal women. • Menopause after age 52 (2.4 times as likely). • Lack of children (twice as likely). • Women with hypertension (twice as likely). • Diabetics (2.8 times as likely). • Women who do not ovulate, in other words those with polycystic ovaries (Stein-Leventhal syndrome). • Estrogen replacement therapy without supplemental progesterone (seven times as likely). • History of pelvic radiation therapy (eight times as likely). • Obesity greater than 23 kg (50 pounds) over ideal body weight (10 times as likely).